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A. De kleijn , , c.
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J. A. Punt department of internal medicine, university medical center st. Radboud, 550 division of medical oncology, po box 9101, 6500 hb nijmegen, the netherlands received 18 december 2001 accepted 11 february 2002 available online 8 march 2002 how to cite or link using doi permissions & reprints view full text purchase $31.
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50 1. viagra 1000 ways die Introduction 2. Immunogenicity and immune evasion in colorectal cancer 3. Non-specific immunotherapy 4. Antibody therapy 5. viagra 10 mg instructions Active specific immunotherapy 6. Conclusions references abstract in this review, the immunogenicity of colorectal cancer (crc) and the results of clinical and recent preclinical studies are discussed.
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Evidence for immune reactivity has been found in several preclinical models and the prognostic value of some of these immune responses have been reported. cheap viagra online usa The possible mechanisms are discussed. Treatment with monoclonal antibodies is still experimental; as previously described benefit of treatment with monoclonal antibodies could not be confirmed.
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Labelled monoclonal antibody therapy has produced mixed results and also need further investigation.
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Several antigens are used in active specific immunotherapy (asi). Its targets and modifications are discussed, as are their use in clinical studies. Although some of the results are promising, the results still have to be confirmed in larger studies. Since there is sufficient evidence for immune reactivity in crc, further research on immunotherapeutic strategies is justified and will be focused on the development of humanised antibodies, the search for other relevant t-cell epitopes and ways to induce a more effective t cell response.
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Keywords colorectal cancer; immune therapy; clinical/preclinical models there are no figures or tables for this document. Corresponding author.
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